The former SuperSport United, Richards Bay and Sekhukhune United mentor replaces Clinton Larsen following his poor start to the new First Division season.
Larsen led Venda to ninth place on the league standings last term but his now former team currently sit in 16th place with just one point from their opening five games.
Part of a Venda statement read: "CEO Dr Rendani Mulaudzi officially welcomed our new Head Coach, Kaitano Tembo, to the clubhouse this morning.
"The hard work starts now as Coach Tembo takes the reins and prepares the squad for the battles ahead. A massive welcome."
Venda are next in action against 12th-placed Midland Wanderers after the international break on October 10, 2026.
