The biggest change comes with the retirement of club captain Linda Mntambo, marking the end of an important era for Babina Noko.
Alongside Mntambo's departure, the club has also released experienced campaigners Lebogang Phiri, Bradley Grobler, Lesiba Nku, Thabang Monare, Sikhosonke Langa, Shaune Mogaila and Rivaldo Coetzee, iDiski Times reported.
Ronaldo Maarman and Sphiwe Mahlangu have also moved on after spending the second half of last season on loan at Durban City.
The departures underline Sekhukhune's intention to refresh the squad as they prepare for life under new head coach Cedric Kaze, who is expected to arrive later this week to officially begin work with the team during pre-season.
With indications that more exits could follow and interest continuing to grow around several key players, Kaze may inherit a significantly reshaped squad by the time the new season gets underway.
Sekhukhune have already started rebuilding by bringing in Bethuel Muzeu, Athenkosi Mcaba and Thabang Mahlangu to strengthen key areas, while striker Chibuike Ohizu returns to the club following his loan spell at Siwelele.
After ending last season in fifth position, Babina Noko will hope their aggressive squad restructuring can provide the platform to challenge more strongly for a top three finish next season.
