The 33-year-old turned out for a number of clubs since coming through the ranks of ASD Cape Town, including Belgian club KSC Lokeren, South African side Cape Town City and Iran Pro League team Esteghlal FC.
Patosi played for Motsepe Foundation Championship newbies Hope FC last term before an injury cut short his season.
He has now joined the recently formed One FC, following their purchase of the status of Western Cape ABC Motsepe club Nanini Na All Stars.
"Ayanda Patosi is ONE,” the club stated.
"We are proud to welcome 33-year-old Ayanda Patosi to One Football Club.
"Welcome to The Ones, Pato!"
